UK Bio- Pharmaceutical and Nutraceutical companies
1. Magnitude Biosciences
Website: https://magnitudebiosciences.com
Company profile:
We are a specialist Contract Research Organisation (CRO) who help the biopharma and nutraceutical industries progress their research projects via our team of expert scientists, C. elegans services and unique automated imaging technology. Our C. elegans studies are customised to answer your key research questions and generate high-quality, reproducible data to accelerate your research. elegans has many useful applications for furthering research across these biopharma and nutraceuticals and, with the right technology, assays, and C. elegans expertise, these tiny worms are enabling big breakthroughs in R&D projects. Some of these applications include:
- We have developed methods to quantify the toxicity of key components used in manufacturing. We assess your compounds for acute, reproductive and chronic toxicity.
- We work with the yeast and health product industries to assess whether your probiotics, prebiotics or bacterial strains are effective in improving health.
- We work with nutrition and nutraceutical companies to assess the impact of your compounds on improving the health of organisms.
- We work with companies interested in assessing how ‘green’ and environmentally friendly their products are via environmental toxicity studies.
- C. elegans are an ethical alternative to rodents and other mammalian animal studies, so we help brands who want to ensure their testing practices are ethical while still being able to see what impact they have on whole organisms’ health.
You may be new to using C. elegans, but we are highly experienced at matching your research area with their utility as an animal model. See the testimonials from nutraceutical companies we’re working with, including NNB Nutrition and Brilliant Science:
https://magnitudebiosciences.com/testimonials/Magnitude Biosciences
2. Fusion Antibodies
Website: www.fusionantibodies.com
Company profile:
Established in 2001, Fusion Antibodies are a Collaborative Research Organisation (CRO) with its headquarters based in Northern Ireland. We provide antibody discovery, engineering and supply, through to cell line development and have guided hundreds of projects through critical preclinical stages and Our scientists, who are experts in early stage discovery of biologics, are dedicated to the discovery and early development of antibodies to help bring about a positive change in the healthcare industry.
Through our vast experience we have developed a number of our own proprietary platforms for Antibody Humanization (CDRx™), Affinity Maturation (RAMP™) and Developability optimisation (ADD™). Our world-class humanization and antibody optimization platforms harness the power of the natural somatic hypermutation space. To address remaining market needs in antibody discovery, Fusion is creating a breakthrough fully human antibody library (OptiMAL®) to capture the entire human antibody repertoire.
3. 4BIO Capital
Website: www.4biocapital.com
Company profile:
4BIO Capital is an international venture capital firm focused solely on the advanced therapies sector. 4BIO’s objective is to invest in, support, and grow early stage companies developing treatments in areas of high unmet medical need, with the ultimate goal of ensuring access to these potentially curative therapies for all patients. Specifically, it looks for viable, high-quality opportunities in cell and gene therapy, RNA-based therapy, targeted therapies, and the microbiome. The 4BIO team comprises leading advanced therapy scientists and experienced life science investors who have collectively published over 250 scientific articles in prestigious academic journals including Nature, The Lancet, Cell, and the New England Journal of Medicine. 4BIO has both an unrivalled network within the advanced therapy sector and a unique understanding of the criteria that define a successful investment opportunity in this space.
4. Origin
Website: www.originltd.com
Company profile:
Origin group combines excellence in packaging design and manufacturing expertise across multiple disciplines with an enduring attention to supply chain efficiencies. They design, manufacture and deliver innovative pharmaceutical & healthcare packaging and device solutions.
Brief profile of the company
Pharmaceutical packaging design and development
Cleanroom Manufacturing Plastic (moulding and assembly) – T he design and installation of a state-of-the-art cleanroom production facility that strictly adheres to ISO 7 class 10,000 and ISO 8 class 100,000, which each ensure the reliable prevention and control of airborne particles.
Form, fill and seal Snappd Sachets
Aseptic Filling Services - Their state-of-the-art liquid filling facility has been specifically designed to meet and surpass the stringent regulations laid out by ISO standards, ensuring that it consistently provides suitable and versatile environments for aseptic filling.
5. Mechatronic
Website: http://mechtech.group/mechatronic/
Company Profile:
With over 30 years’ industry experience, Mechatronic is one of the UK’s leading providers of bespoke automated solutions and system integration services to a range of industry sectors. Our strength is the combination of innovative technology with the experience and expertise of our dynamic team. We solve complex manufacturing challenges achieving Beyond Smart results and profitability for our customers.
Mechatronic’s assembly platform is specifically designed for medical device assembly, test, inspection, labelling, and packing applications. It combines fully programmable linear pallet transfer and component handling systems enabling exceptional precision, flexibility, repeatability and speed.
Fully configurable to a variety of lengths, pallet sizes and number of stations for a multitude of medical devices including injection and auto-injection devices, inhalers, vascular devices and diagnostic units.
Compliant to strict assembly standards and integrated with smart factory control, Mechatronic’s platform places tracking and traceability of batch information and assembly data at your finger tips, along with connectivity to your MES or ERP systems.
6. Alcyomics Ltd
Website: www.alcyomics.com
Company profile:
Alcyomics is a service provider, specialising but not limited to predicting adverse immune reactions to novel compounds and drugs including, monoclonal antibodies and cellular therapies and has 3 EU and US patents with one further patent filed. Alcyomics Skimune® platform uses human skin biopsies and blood samples , with local research ethics committee approval, to assess novel drugs and compounds for adverse immune reactions with readouts including T cell proliferation, cytokine release and histopathological damage, a unique,accurate and sensitive readout. The assay, unlike others on the market covers all aspects of the Adverse Outcome Pathway.
Alcyomics has clients in the USA, Europe and Japan and includes some of the top ten pharma and cosmetics companies. We have also worked with companies in the medical device industry and have assessed complex formulations. We currently carry out assays to IS9001 standard, where the results go towards the investigative medical product dossier for regulatory approval in both the UK and Japan. In addition
Alcyomics also specialises in disease models ( osteoarthritis and skin disease- atopic dermatitis) using human derived cell lines and or human skin tissue for drug screening, efficacy and drug discovery . Alcyomics can also offer a range of OECD approved assays covering skin corrosion, sensitisation, irritation, wound healing (scratch assays) and senescence assays for assessment of compounds targeted at the aging process. Benefits to users of Alcyomics assays enable cost saving in reducing the need for extensive animal experimentation, accurate prediction of systemic and skin adverse immune events, sensitive drug efficacy testing and novel platforms for drug discovery.
7. Eagle Genomics
Website: https://www.eaglegenomics.com/
Company Profile:
Eagle Genomics is innovating at the intersection of biology and data sciences to help drive the digital reinvention of the life sciences. Its award-winning AI-augmented knowledge discovery platform, e[datascientist]™, empowers scientists to exploit multi-dimensional data to help companies conduct science-led innovation for next-generation products. It supports the entire innovation workflow - from hypothesis through insight to evidence-based product claims, in minutes rather than months – reducing ‘trial and error’ and helping to bring novel, safer and more sustainable products to market.
Applicability of solutions
- Enables easier hypothesis-led and targeted collaboration with scientists
- Intuitive application architecture enables the systemization of innovation across scientific R&D, enhanced by Eagle Genomics’ strategic relationships with leading scientific establishments.
- Best-in-class applications and datasets for scientific and data analysis, at microbiome-type scales
Impactful Highlights
Eagle Genomics is making an impact is understanding the role of the microbiome in health & wellness:
- Eagle Genomics has supported GSK, in collaboration with the University of Edinburgh Department of Clinical Surgery, to seek better molecular biomarkers for acute pancreatitis, using a systems biology approach.
- Eagle Genomics also works with global company Unilever which uses microbial genetic data as part of its consumer R&D strategy, applying such insights to products. Eagle Genomics applies its expertise and platform to analyze and understand Unilever’s existing approach.
- The Company also works with Cargill, one of the world’s largest food and agricultural companies in the world, helping investigate the relationship between the microbiome and digestive and immune health across several species.
Award highlights
- Listed as Top 500 Deep Tech Pioneer by Hello Tomorrow
- ‘AI Champion’ winner in the UK’s Business Weekly’s 2021 Awards.
- European Institute of Innovation & Technology (EIT) Food RisingFoodStar
8. Aeirtec Limited
Website: www.aeirtec.com
Company Profile:
Aeirtec have a clinical pharmacology/pharmacology background and within 2 decades of experience in running clinical trials, they have 2 decades of blood marker data provision in efficacy, drug candidate mechanism of action, translation and exploratory marker changes in clinical studies (phase II and III). Aeirtec have patented technology for unique high sensitivity clinical study blood marker immunoassay (1, 2) and so provide the highest sensitivity immunoassay in studies requiring simultaneous measurement of multiple clinal markers (eg greater than 10 marker multiplexing). The marker multiplexing enables economies in cost and a magnitude greater data acquisition from clinical samples.
Aeirtec have establish a 20 marker panel for monitoring COVID-19-induced ARDS markers that has revealed clinical efficacy against the ARDS immune /inflammatory profile (3)
Aeirtec advises on marker panel choice within the therapeutic context and this is supported by post study provision of in depth multivariate statistical analysis for demonstration of candidate efficacy and mechanism of action (eg 4).
Biotech clients of Aeirtec are maintaining a working relationship with Aeirtec for over a decade, as Aeirtec helps them move their candidates through development phases to a position of out-licencing and approval.
Aeirtec is located in the UK, working under compliance with the principles of GLP and ISO17025 and their broad clinical study expertise has evolved from clinical study engagement with both biotech and pharma (Aeirtec client examples: AstraZeneca, Altana, Athersys, Bayer, Boehringer Ingelheim, Cara Therapeutics, GlaxoSmithKline, Novartis, Pfizer, UCB)
(1) Patent issued: Immobilised bead immunomultiplex assay US2013157288A1 (B2) https://patents.google.com/patent/US20130157288A1/en22
(2) Patent pending: Assay analysis WO2020120996 (A1) https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020120996
(3) http://www.aeirtec.com/cytokine-storm/4595038618
(4) https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30046-7/fulltext
9. NIHR - National Institute for Health research
Website: https://www.nihr.ac.uk/partners-and-industry/industry/
Company Profile:
As a leading destination for clinical research, the NIHR can support life science companies to generate the required clinical and economic evidence to progress the development of their new therapeutics, MedTech, diagnostics and digital products towards the market.
They provide a full range of support to innovators throughout their clinical evaluation, from early stage translational research through to later stage clinical trials and investigations in the NHS and social care settings.
NIHR have a unique view on the strengths, capabilities and interest of over 25,000 researchers
across our country’s leading universities and NHS trusts. They can support in connecting with
expert clinicians, world-leading academics, technical specialists, health economists, statisticians
and support staff across a very wide range of disease and technical specialities.
10. Pangaea Data Limited
Website: www.pangaeadata.ai
Company Profile:
Pangaea Data is headquartered in London with offices in San Francisco and Hong Kong. Pangaea provides an AI driven software product, which has proven to find 50% more suitable patients including those who are undiagnosed and to automatically generate clinical narratives for regulatory reports thereby saving 80 - 90% in time. This is achieved through Pangaea's novel unsupervised Natural Language Processing (NLP) and first of its kind Natural Language Generation (NLG) methods which respectively extract and summarize intelligence from textual and multi-modal health data at scale and in a federated privacy preserving manner. Pangaea's product has demonstrated 85 - 90% accuracy through high impact peer reviewed publications, which is transformatively higher than generic language models like GPT-3, supervised NLP, and relational extraction approaches.
Pangaea's product has successfully scaled in the pharmaceutical and healthcare industry and has been presented by leading clinicians and scientists at global conferences. The founders at Pangaea have secured more than £130 million in research funding through their work. All customer success stories and peer reviewed publications including comparisons to alternative approaches with evidence of efficacy through a combination of context, reinforcement learning, and 'human experts (clinicians) in the loop' are available freely through Pangaea's website.
11. Optibiotix
Website: https://optibiotix.com/
Company Profile:
OptiBiotix Health Plc. is a life sciences company operating in one of the most progressive areas of biotechnological research.
Developing technologies that modulate the human microbiome – the collective genome of the microbes in the body – OptiBiotix identifies and develops microbial strains, compounds and formulations for use in food ingredients, supplements and active compounds that can impact on human physiology, deriving potential health benefits.
OptiBiome®:
A high throughput technology platform that screens identifies and/or develops microbiome modulators, which can be used in proprietary formulations to prevent, manage, and a wide range of chronic lifestyle diseases. SlimBiome®, the first product commercialised, is used to manage weight to help ensure an individual’s health and wellbeing.
Transforming the way cardiovascular health is approached, CholBiome is a range of unique food supplements that harnesses the power of the patented probiotic LPLDL® either on its own or in combination with other natural, science-backed ingredients to help improve cardiovascular health.
Offering a holistic alternative to pharmaceutical treatments, this innovative range is specialised in helping support core areas of heart health. These include reducing cholesterol and blood pressure and supporting vascular health to promote overall heart wellness.